Synthesis of N-substituted 2-[(1E)-alkenyl]-4-(1H)-quinolone derivatives as antimycobacterial agents against non-tubercular mycobacteria

► Synthesis of 30 new N-substituted-2-[(1E)-alkenyl]-4-(1H)-quinolones. ► MIC till 0.5 mg/L against one of the fast growing Mycobacteria in vitro. ► Substituents at N-1 influence the antimycobacterial activity. ► Best activity with 13-15 C-atoms overall in both side chains.