Efficient microwave-assisted synthesis and antitumor activity of novel 4,4′-methylenebis[2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols]

► In this work we have synthesized two new series of bis-pyrazolines derivatives. ► Bis-pyrazolines compounds are obtained by microwave-assisted reaction. ► This synthesis allowed the formation of the desired compounds in excellent yields. ► Biological assays show that two compounds are active in several tumor cell lines. ► These compounds exhibited promising activities in accord whit GI50 and LC50 values.