Lead optimization of 4-imidazolylflavans: New promising aromatase inhibitors

► 4-Imidazolylflavans are potent inhibitors of aromatase. ► New synthesized 7,8-benzo-4-imidazolylflavans are highly active. ► Great influence of stereochemistry on biological effect was demonstrated. ► Modulation of flavonoids could provide new promising aromatase inhibitors.