Synthesis and antimicrobial activity of some new 4-hetarylpyrazole and furo[2,3-c]pyrazole derivatives

► A new series of 4-hetarylpyrazoles and furo[2,3-c]pyrazoles were synthesized. ► The antimicrobial activity of new compounds have been screened. ► Compound 12 showed equipotent activity with chloramphenicol against B. subtilis (MIC 3.125 μg/mL). ► Compounds 7 and 13 were found to exhibit the most potent in vitro antifungal activity. ► The attachment of furyl moiety to pyrazole ring is crucial in developing a new antimicrobial agent.