Synthesis and antifungal activity of some substituted phenothiazines and related compounds

► Some phenothiazine compounds have been prepared and evaluated as antifungal agents. ► We found that only PMZ, PIP, and compound 6 showed interesting activity. ► Compound 6 showed to be as active as antifungal agents currently used in clinical. ► There are not breakpoints for antifungal drugs, however 6 could be a promising drug.