Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities

► Novel acrylic acids were designed as dual lipoxygenase/cyclooxygenase-1 (LOX/COX-1) inhibitors. ► Modifications implicate thienyl, furfuryl, 3,5-ditert-butyl-4-hydroxyphenyl at the 3 position. ► Most of them proved to be potent antioxidant and anti-inflammatory agents. ► The most active compounds docked successfully into the active site of the inhibited enzymes. ► Compounds 1II and 2II inhibit LOX and COX-1 and present anti-inflammatory and antioxidant activities.