Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives

► New quinoxalines derivatives have been synthesized to evaluate their cancer chemopreventive activity. ► The inhibitory effects of compounds 1-21 on Epsteine Barr virus early antigen (EBV-EA) activation induced by TPA have been studied. ► The in vivo two-stage carcinogenesis test of compound 12 was studied. ► The synthesized compounds docked into c-kit protein-tyrosine kinase.