CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes

► NAH framework is resistance to biotransformations promoted by rat liver microsomes. ► Cathecol metabolite is resultant from oxidative cleavage of LASSBio-294. ► CYP1A2 isoform is involved in oxidative clearance of LASSBio-294.