Reactivity kinetics of 52S4 glass in the quaternary system SiO2-CaO-Na2O-P2O5: Influence of the synthesis process: Melting versus sol-gel

► We highlight the kinetics reactivity of a glass containing high sodium oxide. ► Two synthesis methods are used: melting and sol-gel routes. ► Bone-like apatite was formed at surface of glass prepared by the two routes. ► However, sol-gel glass exhibits properties for high kinetics of bioactivity. ► Also, it leads to silica gel formation up on amorphous apatite layers at any time.