Preparation of organic-functionalized mesoporous ZSM-5 zeolites by consecutive desilication and silanization

► Sequential desilication and silanization yields ZSM-5 zeolites with functionalized intra-crystalline mesopores. ► Combination of post-synthesis methods tailors porous and surface properties of zeolites. ► Uptake and retention of lipase enzymes enhanced in organic-functionalized mesoporous ZSM-5 zeolites.