کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
810709 1469101 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Combinatorial therapy using negative pressure and varying lithium dosage for accelerated wound healing
ترجمه فارسی عنوان
درمان ترکیبی با استفاده از فشار منفی و دوز متفاوت لیتیوم برای بهبود زخم شتاب
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی

In this work, we investigated the effects of negative pressure, applied using a pump designed for Negative Pressure Wound Therapy (NPWT), on the process of wound healing in vitro via initiation of the Wnt signaling pathway. Results indicate that negative pressure enhanced Wnt signaling and migration into a simulated wound in vitro in NIH-3T3 murine fibroblast cells. Increasing doses of lithium (upto 15 mM) increased basal Wnt signaling and enhanced cell migration into the simulated wound site. A combination of negative pressure and increased doses of lithium synergistically increased Wnt signaling and demonstrated further enhanced cell migration into simulated wound sites, with maximal filling of the simulated wound observed at lithium concentrations of at least 10 mM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 44, April 2015, Pages 173–178
نویسندگان
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