کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8144994 1524065 2018 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stability analysis and control of the glucose insulin glucagon system in humans
ترجمه فارسی عنوان
تجزیه و تحلیل ثبات و کنترل انسولین گلوکاگون گلوکز در انسان
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک اتمی و مولکولی و اپتیک
چکیده انگلیسی
The goal for the treatment of type-1 diabetes mellitus is the development of an artificial pancreas to regulate the blood glucose level in a closed loop design. A system of nonlinear differential equations having five variables (glucose, insulin, β-cell mass, α-cell mass, and glucagon) with seventeen parameters is considered. The Lyapunov function is used to check the stability analysis of the model. Controllability and observability of the linearized model are discussed under two different cases: in case 1 insulin is taken as an input, and in case 2 insulin and glucagon are taken as inputs for the system. This model played an important role in the development of a fully automatic artificial pancreas by stabilizing the control loop system for the glucose-insulin glucagon pump. A proportional integral derivative (PID) controller is designed for an artificial pancreas by using the transfer function. According to the desired value, the algorithm of an artificial pancreas measures the glucose level in the blood of a patient by using a glucose sensor that sends a signal to an insulin glucagon pump to adjust the basal insulin. A closed-loop system is tested in the Simulink environment, and the simulation results show the performance of the designed controller.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Physics - Volume 56, Issue 4, August 2018, Pages 1362-1369
نویسندگان
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