کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8159829 1524992 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ex vivo mouse brain microscopy at 15T with loop-gap RF coil
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
Ex vivo mouse brain microscopy at 15T with loop-gap RF coil
چکیده انگلیسی
The design of a loop-gap-resonator RF coil optimized for ex vivo mouse brain microscopy at ultra high fields is described and its properties characterized using simulations, phantoms and experimental scans of mouse brains fixed in 10% formalin containing 4 mM Magnevist™. The RF (B1) and magnetic field (B0) homogeneities are experimentally quantified and compared to electromagnetic simulations of the coil. The coil's performance is also compared to a similarly sized surface coil and found to yield double the sensitivity. A three-dimensional gradient-echo (GRE) sequence is used to acquire high resolution mouse brain scans at (47 μm)3 resolution in 1.8 h and a 20 × 20 × 19 μm3 resolution in 27 h. The high resolution obtained permitted clear visualization and identification of multiple structures in the ex vivo mouse brain and represents, to our knowledge, the highest resolution ever achieved for a whole mouse brain. Importantly, the coil design is simple and easy to construct.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 51, September 2018, Pages 1-6
نویسندگان
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