کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8203279 1530513 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic disorder characteristics of single-molecule pulling experiments on two-dimensional free-energy landscape
ترجمه فارسی عنوان
خصوصیات اختلال پویایی آزمایشهای تک مولکولی در زمینه چشم انداز آزاد انرژی دو بعدی
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک و نجوم (عمومی)
چکیده انگلیسی
The dynamic characteristic of macromolecule is mainly subject to the fluctuation of rate constant and this phenomenon is usually considered as dynamic disorder (DD). In order to detect the DD nature in the bio-molecule system more accurately, here we propose a theoretical framework based on the two-dimensional (2D) free-energy landscape including the pulling coordinate and other slow conformational variables. The generalized Langevin equation (GLE) with fractional Gaussian noise (fGn) and the power-law memory kernel are used on this landscape for the research. The transition rate, which depends on both intrinsic barrier height and noise strength ratio, has been analyzed under the condition of external force. The particular discrepancies were investigated between the kinetics of the transitions with and without DD. We find that the discrepancies relied on the barrier height and the noise strength ratio. Taken together, our study illustrates the importance of the DD characteristics, which should be taken into account during the research into the single-molecule pulling experiments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physics Letters A - Volume 382, Issue 27, 11 July 2018, Pages 1791-1795
نویسندگان
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