کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
820936 | 906733 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Fabrication and characterization of poly-d-l-lactide/nano-hydroxyapatite composite scaffolds with poly (ethylene glycol) coating and dexamethasone releasing Fabrication and characterization of poly-d-l-lactide/nano-hydroxyapatite composite scaffolds with poly (ethylene glycol) coating and dexamethasone releasing](/preview/png/820936.png)
The control of pore size and structure, drug release capacity, and biodegradation of scaffolds is of importance for bone tissue engineering. In this study, a technique combining polymer coagulation, cold compression molding, salt particulate leaching and drug coating method was developed to fabricate poly (ethylene glycol)/dexamethasone coated porous poly-d-l-lactide/nano-hydroxyapatite (PDLLA/nano-HAp) scaffolds. These scaffolds possess homogenous pore networks with high porosity (66–82%) and controllable pore size (200–300 μm). The compressive moduli and strength of the scaffolds after incorporation of nano-HAp were improved by 50% and 20%, respectively. The surface hydrophilicity of the scaffold was significantly improved by poly (ethylene glycol)/dexamethasone coating and nano-HAp addition, leading to a higher initial drug loading amount. The results showed that the drug release behavior of the scaffolds after 35-day immersion in water could be adjusted by varying the porosity level and by incorporation of 20 wt.% of nano-HAp.
► Method with salt particle leaching, polymer coagulation & cold compression molding.
► Producing composite scaffolds with homogeneous pore network & adjustable pore size.
► Adjusting drug release behavior of the scaffolds by varying porosity & nano-HAp.
► Enhancing the mechanical properties of the scaffolds with nano-HAp addition.
► Improving surface hydrophilicity of the scaffold through PEG/Dex coating & nono-HAp.
Journal: Composites Science and Technology - Volume 71, Issue 16, 14 November 2011, Pages 1842–1849