Radiation Dose, Local Disease Progression, and Overall Survival in Patients With Inoperable Non-Small Cell Lung Cancer After Concurrent Chemoradiation Therapy

Squamous histology, large tumor volumes, and receipt of induction chemotherapy all predicted worse LPFS. Doses of 67 to 70 Gy were associated with improved LP-free survival after chemoradiotherapy. The link between LP and reduced OS suggests that more effective local control strategies are warranted.