Long-Term Quality of Life After Swallowing and Salivary-Sparing Chemo-Intensity Modulated Radiation Therapy in Survivors of Human Papillomavirus-Related Oropharyngeal Cancer

At more than 6 years' median follow-up, OPC patients treated with swallowing and salivary organ-sparing chemo-IMRT reported stable or improved HRQOL in nearly all domains compared with both before treatment and 2-year follow-up. New late toxicity after 2 years was uncommon. Further emphasis on sparing the swallowing organs may yield additional HRQOL gains for long-term OPC survivors.