Modelling the Impact of Fractionation on Late Urinary Toxicity After Postprostatectomy Radiation Therapy

The unexpected impact of moderate hypofractionation on severe incontinence and hematuria after postprostatectomy radiation therapy may be explained by a bladder α/β value <1 Gy or, radiobiologically more plausible, by introducing a time factor likely to represent a previously hypothesized consequential component of late effect.