Ionizing Radiation-Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2

Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor suppressor that inhibits cell proliferation by targeting cyclin A2.