Clinical Value of [11C]Methionine PET for Stereotactic Radiation Therapy With Intensity Modulated Radiation Therapy to Metastatic Brain Tumors

We showed examples of metastatic lesions demonstrating significant decreases in MET uptake following SRT-IMRT. MET-PET seems to have a potential role in providing additional information, although MRI remains the gold standard for diagnosis and follow-up after SRT-IMRT. The present study is a preliminary approach, but to more clearly define the impact of PET-based radiosurgical assessment, further experimental and clinical analyses are required.