کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8225380 | 1533069 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Computational Model of Cellular Response to Modulated Radiation Fields
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A Computational Model of Cellular Response to Modulated Radiation Fields A Computational Model of Cellular Response to Modulated Radiation Fields](/preview/png/8225380.png)
چکیده انگلیسی
The model presented in this work accurately reproduces cell survival following modulated radiation exposures, both in and out of the primary treatment field, by incorporating a bystander component. In addition, the model suggests that the bystander effect is responsible for a significant portion of cell killing in uniformly irradiated cells, 50% and 70% at doses of 2 Gy in AGO1522 and DU145 cells, respectively. This description is a significant departure from accepted radiobiological models and may have a significant impact on optimization of treatment planning approaches if proven to be applicable in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Radiation Oncology*Biology*Physics - Volume 84, Issue 1, 1 September 2012, Pages 250-256
Journal: International Journal of Radiation Oncology*Biology*Physics - Volume 84, Issue 1, 1 September 2012, Pages 250-256
نویسندگان
Stephen J. Ph.D., Karl T. Ph.D., Conor K. M.Sc., Colman B.Sc., Joe M. FRR(RCSI), Alan R. Ph.D., Kevin M. Ph.D.,