Evaluation of Microscopic Disease in Oral Tongue Cancer Using Whole-Mount Histopathologic Techniques: Implications for the Management of Head-and-Neck Cancers

In this study we were able to assess the distribution of MD more accurately than has been possible with routine pathologic techniques. The results indicate that when the GTV is correctly identified, there is very little MD to be found outside this volume. This has implications for the volume of tissue resected at surgery and the volume included in the clinical target volume in conformal radiotherapy planning.