Comparison Between High and Low Source Activity Seeds for I-125 Permanent Seed Prostate Brachytherapy

Higher seed activity (I125 ≥ 0.6 mCi) results in at least equal V100 and D90 on CTD30. However, dose inhomogeneity and a trend toward more urinary toxicity at 4 and 8 months after treatment may lead to a higher long-term urinary complications.