کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8233612 | 1533110 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Radiation Dose-Volume Effects in Radiation-Induced Rectal Injury
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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چکیده انگلیسی
The available dose/volume/outcome data for rectal injury were reviewed. The volume of rectum receiving â¥60Gy is consistently associated with the risk of Grade â¥2 rectal toxicity or rectal bleeding. Parameters for the Lyman-Kutcher-Burman normal tissue complication probability model from four clinical series are remarkably consistent, suggesting that high doses are predominant in determining the risk of toxicity. The best overall estimates (95% confidence interval) of the Lyman-Kutcher-Burman model parameters are n = 0.09 (0.04-0.14); m = 0.13 (0.10-0.17); and TD50 = 76.9 (73.7-80.1) Gy. Most of the models of late radiation toxicity come from three-dimensional conformal radiotherapy dose-escalation studies of early-stage prostate cancer. It is possible that intensity-modulated radiotherapy or proton beam dose distributions require modification of these models because of the inherent differences in low and intermediate dose distributions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Radiation Oncology*Biology*Physics - Volume 76, Issue 3, Supplement, 1 March 2010, Pages S123-S129
Journal: International Journal of Radiation Oncology*Biology*Physics - Volume 76, Issue 3, Supplement, 1 March 2010, Pages S123-S129
نویسندگان
Jeff M. M.D., Hiram M.D., Andrew M.D., Susan L. Ph.D., Joseph O. Ph.D.,