Imaging After GliaSite Brachytherapy: Prognostic MRI Indicators of Disease Control and Recurrence

After GliaSite treatment, characteristic T1- and T2-weighted changes are seen on MRI. Greater T1-weighted changes in the absence of increasing edema appears not to indicate disease progression; however, greater T2-weighted changes were associated with decreased survival. These findings suggest that T1-weighted enhancement in the absence of concomitant edema after GliaSite treatment might represent pseudoprogression. Conversely, increasing T2-weighted hyperintensity might reflect infiltrative disease progression. These results provide a framework for the analysis of disease control in future prospective studies of GliaSite treatment.