کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8237929 | 1533133 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased But Error-Prone Nonhomologous End Joining in Immortalized Lymphoblastoid Cell Extracts From Adult Cancer Patients With Late Radionecrosis
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
These findings are consistent with the suggestion that a promiscuous, deletion-prone abnormality of nonhomologous end joining might underpin the predisposition of certain radiotherapy patients to late radionecrosis. We hypothesize that some individuals might harbor subclinical defects in nonhomologous end joining that clinically manifest on challenge with high-dose radiation. Because both quantitative and qualitative aspects of end joining have demonstrably been influenced, we recommend that the study of patient samples should involve a combination of quantitative methods (e.g., quantitative real-time polymerase chain reaction), sequencing analysis, and a comparison of multiple join types.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Radiation Oncology*Biology*Physics - Volume 72, Issue 1, 1 September 2008, Pages 178-185
Journal: International Journal of Radiation Oncology*Biology*Physics - Volume 72, Issue 1, 1 September 2008, Pages 178-185
نویسندگان
Wu-Meng M.B.B.Chir., Ph.D., Malcolm C. Ph.D., Ghee Chong Ph.D., Hui Hua Ph.D., Allan Ph.D., F.R.C.R., F.R.C.P., Susan L.E. M.D., F.R.C.R., F.R.C.P.,