Vessel Size Index Magnetic Resonance Imaging to Monitor the Effect of Antivascular Treatment in a Rodent Tumor Model

The vessel size index results were consistent with the known action of DMXAA to cause vascular collapse, with histogram analysis of the fBV providing the most sensitive indicator of response. In particular, the parameter, the fraction of tumor with an fBV of ≤1% is a potential biomarker that correlates with the histopathologic measure of tumor necrosis.