Clinical and Dosimetric Predictors of Late Rectal Syndrome After 3D-CRT for Localized Prostate Cancer: Preliminary Results of a Multicenter Prospective Study

The predictive value of the dose-volume histogram was confirmed for bleeding, consistent with previously suggested constraints (V50 <55%, V60 <40%, V70 <25%, and V75 <5%). A dose-volume histogram constraint for incontinence can be suggested (V40 <65-70%). Previous abdominal/pelvic surgery correlated with all toxicity types; thus, a modified constraint for bleeding (V70 <15%) can be suggested for patients with a history of abdominal/pelvis surgery, although further validation on a larger population with longer follow-up is needed.