Reproducibility of Intratumor Distribution of 18F-Fluoromisonidazole in Head and Neck Cancer

Variability in spatial uptake can occur between repeat 18F-FMISO PET scans in patients with head and neck cancer. Blood data for one patient was not available. Of 13 patients, 6 had well-correlated intratumor distributions of 18F-FMISO-suggestive of chronic hypoxia. More work is required to identify the underlying causes of changes in intratumor distribution before single-time-point 18F-FMISO PET images can be used as the basis of hypoxia-targeting intensity-modulated radiotherapy.