Comparison of Five Segmentation Tools for 18F-Fluoro-Deoxy-Glucose-Positron Emission Tomography-Based Target Volume Definition in Head and Neck Cancer

The choice of segmentation tool for target-volume definition of head and neck cancer based on FDG-PET images is not trivial because it influences both volume and shape of the resulting GTV. With adequate delineation, PET may add significantly to CT- and physical examination-based GTV definition.