α/β ratio: A dose range dependence study

Conclusion: The dependence of the fitted α and β on the dose range has an impact on the α/β ratio determined from the survival data. The low-dose region had a significant influence that could be a result of a strong linear, rather than quadratic, component, hypersensitivity, and adaptive responses. This dose dependence should be interpreted as a caution against using inadequate in vitro cell survival data for α/β ratio determination.