PSA nadir predicts biochemical and distant failures after external beam radiotherapy for prostate cancer: A multi-institutional analysis

Conclusion: The results of this large, multi-institutional analysis of 4833 patients have provided important evidence that nPSA and TnPSA after definitive external beam RT are not only predictive of a predominantly PSA endpoint (PSA-DFS), but are also predictive of distant metastasis in all clinical risk categories. Greater RT doses were associated with lower nPSA, longer TnPSA, and improved PSA-DFS and DMFS.