کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8262234 1534835 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aberrant signaling and senescence associated protein degradation
ترجمه فارسی عنوان
تضعیف پروتئین های بی خطر و پیری
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Senescent cells accumulate with age and contribute to pathologies associated to old age. The senescent program can be induced by pro-cancer stimuli or is developmentally controlled. In cells forced to senesce by expression of oncogenes or short telomeres, aberrant activation of the ERK/MAP kinase signaling pathway leads to selective protein degradation by the ubiquitin proteasome system. The proteins affected by this process control key cellular processes known to be defective in senescent cells. We discuss the evidence supporting a general role for aberrant signaling and senescence associated protein degradation for organismal aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 107, 1 July 2018, Pages 50-54
نویسندگان
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