کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8262624 1400119 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Integrin-linked kinase: A new actor in the ageing process?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Integrin-linked kinase: A new actor in the ageing process?
چکیده انگلیسی
Schematic representation of ILK implication in ageing. (Upper panel) Cellular senescence. Physiological context: ILK is overexpressed in cells from old mice, inducing senescent genes (Chen et al., 2006). Pathological context: ILK is overexpressed in cancer cells, and its repression induces senescence (Zhu et al., 2014 and Duminuco et al., 2015). Some extracellular stressors such as ROS and hyperphosphatemia induce senescence through ILK activation (Troyano et al., 2015; Troyano-Suárez et al., 2015). (Lower panel) Organismal Ageing. Old or hyperphosphatemic animals show increased ILK (Troyano et al., 2015; Troyano-Suárez et al., 2015). Moderate repression (├) or strong repression (╟) of ILK induce different consequences in organisms (Kumsta et al., 2014; Nishimura et al., 2014).143
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 100, 15 December 2017, Pages 87-90
نویسندگان
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