کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8262814 | 1534860 | 2016 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
This study aimed to evaluate the relationship between the cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. A cross-sectional study was conducted with a random and representative sample of 142 elderly subjects selected by cluster and recruited from a municipal assistance program. Clinical, nutritional, biochemical and inflammatory profiles, oxidative stress and genotyping for the BsmI polymorphism were evaluated. Participants had mean age of 69.9 (7.0) years, BMI of 28.3 (4.4) kg/m2 and 80.3% were women. The prevalence of a 25-hydroxyvitamin D [25(OH)D] status < 75 nmol/L was 40.8%. A vitamin D level < 75 nmol/L was found to be associated with gender and fish consumption. The INSUF/DEF group [25(OH)D < 75 nmol/L] showed higher fasting blood glucose MDA values when compared to the SUF group [25(OH)D â¥Â 75 nmol/L]; this relationship was maintained only for women in the analysis by sex. The BsmI polymorphism showed allelic frequencies in the SUF group of B 49% and b 51% and in the INSUF/DEF group B 38% and b 62%. The frequency of bb homozygosity was significantly associated with lower serum total cholesterol and LDL cholesterol concentrations compared to Bb, both in the general population and in the SUF group. Among individuals with bb, the INSUF/DEF group showed higher levels of triglycerides and VLDL cholesterol. Blood glucose levels and oxidative stress were increased in elderly subjects with 25(OH)D < 75 nmol/L. The presence of the bb genotype with adequate vitamin D status resulted in lower total and LDL cholesterol, but the benefit was lost when vitamin D insufficiency or deficiency was present.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 81, August 2016, Pages 56-64
Journal: Experimental Gerontology - Volume 81, August 2016, Pages 56-64
نویسندگان
Chahira Taha Mahd Ibrahim Issa, Alexandre Sérgio Silva, Luciana Tavares Toscano, Marcia Silva Medeiros, Darlene Camati Persuhn, Alcides da Silva Diniz, Maria José de Carvalho Costa, Maria da Conceição Rodrigues Gonçalves,