کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8272493 1535071 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Notch3 protein expression in skin fibroblasts from CADASIL patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Notch3 protein expression in skin fibroblasts from CADASIL patients
چکیده انگلیسی
Our results show that the investigated three NOTCH3 mutations are associated with a reduction of the levels of Notch3 expression in vitro. Because the smooth muscle cells appear to be predominantly involved in this cerebrovascular disease, our result, despite the limitation of the sample size examinated, clearly suggest that also fibroblasts, directly involved in making the vascular basal lamina and in maintaining the vascular integrity, may play an important role in the mechanism responsible for the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 390, 15 July 2018, Pages 121-128
نویسندگان
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