کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8274181 | 1535096 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Opening of ATP-sensitive K+ (KATP) channels enhance hydroxyl radical generation induced by MPP+ in rat striatum
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کلمات کلیدی
MPTPMAODHBA1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine1-Methyl-4-phenylpyridinium ion (MPP+) - 1-Methyl-4-phenylpyridinium ion (MPP +)MPP+ - MPP +Parkinson's disease - بیماری پارکینسونDopamine - دوپامینdihydroxybenzoic acid - دی هیدروکسی بنزوئیک اسیدFree radicals - رادیکال آزادHydroxyl radical - رادیکال هیدروکسیلmonoamine oxidase - مونوآمین اکسیدازها Nicorandil - نیکارنگیلCromakalim - کرامکالیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
The present study examined whether opening of adenosine triphosphate (ATP) sensitive K+ (KATP) channels can enhance 1-methyl-4-phenylpyridinium (MPP+)-induced hydroxyl radical (OH) generation in rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/ml per min) was infused through a microdialysis probe to detect the generation of OH as reflected by the non-enzymatic formation of 2.3-dihydroxybenzoic acid (DHBA) in the striatum. MPP+ (5 mM) enhanced generation of OH with concomitant increased efflux of dopamine (DA). Cromakalim (100 μM), a KATP channel opener, through the microdialysis probe significantly increased both DA efflux and OH formation induced by MPP+. Another KATP channel opener, nicorandil (1 mM), also increased the level DA or DHBA, but these changes were not significant. However, in the presence of glibenclamide (10 μM), a KATP channel antagonist, and the increase of MPP+-induced DA or DHBA were not observed. Cromakalim (10, 50 and 100 μM) increased MPP+-induced DHBA formation in a concentration-dependent manner. However, the effects of cromakalim in the presence of glibenclamide were abolished. These results suggest that opening of KATP channels may cause OH generation by MPP+.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 366, 15 July 2016, Pages 180-183
Journal: Journal of the Neurological Sciences - Volume 366, 15 July 2016, Pages 180-183
نویسندگان
Toshio Obata, Michiko Nakashima,