کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8274716 | 1535101 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epstein-Barr virus and multiple sclerosis. From evidence to therapeutic strategies
ترجمه فارسی عنوان
ویروس اپشتین بار و مولتیپل اسکلروز. از شواهد به استراتژی های درمانی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CISHERV-WHERVsEBV - اپشتین بار ویروسCNS - دستگاه عصبی مرکزیHuman endogenous retroviruses - رتروویروسهای انسانی انسانیBBB - سد خونی مغزیBlood–brain barrier - سد خونی مغزیclinically isolated syndrome - سندرم انزال بالینیcentral nervous system - سیستم عصبی مرکزیCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیEpstein–Barr virus - ویروس Epstein-Barr
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Multiple sclerosis is caused by a complex interaction between genetic predisposition and environmental factors. Epstein-Barr virus (EBV) is an environmental risk factor that is strongly related to multiple sclerosis (MS), since EBV seropositivity is linked to a significant risk of developing MS. EBV may be involved in the pathogenesis of the disease and it is possibly a prerequisite for the development of MS. EBV infection persists in B-cells during the lifetime of the host and can modulate their function. In addition, MS patients might have a deficient capacity to eliminate latent EBV infection in the central nervous system and this would promote the accumulation of infected B cells. Several mechanisms of pathogenesis, including a direct and indirect function of infected B cells, have been postulated in inflammation and neurodegeneration. A relationship between EBV and human endogenous retroviruses in the pathogenesis of MS has also been reported. If EBV is important in the pathogenesis of MS, different therapeutic strategies seem possible for MS treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 361, 15 February 2016, Pages 213-219
Journal: Journal of the Neurological Sciences - Volume 361, 15 February 2016, Pages 213-219
نویسندگان
Santiago Fernández-Menéndez, Marta Fernández-Morán, Iván Fernández-Vega, Angel Pérez-Álvarez, Javier Villafani-Echazú,