کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8274997 1535102 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polyglucosan bodies in intramuscular nerves: Association with muscle fiber denervation atrophy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Polyglucosan bodies in intramuscular nerves: Association with muscle fiber denervation atrophy
چکیده انگلیسی
Polyglucosan bodies (PB) in the intramuscular nerves have been rarely studied, and their presence particularly in subjects without neurologic disorders has been thought to be age-related. We examined, by using light and electron microscopy, 204 consecutive muscle biopsies. PB was found in 5 quadriceps intramuscular nerves (2.45% of all biopsies). All 5 quadriceps containing PB exhibited varying degrees of muscle fiber denervation atrophy with or without fiber type grouping. These quadriceps with PB, compared with the other 119 quadriceps without PB, showed a significantly greater association with muscle fiber denervation atrophy (5/5 versus 55/119; p = 0.02, by two-tailed Fisher's exact test), for which aging is not confounding. Electron microscopy identified PB in intramuscular nerve myelinated fibers along with ongoing degenerative changes. Our observation suggests that PB in intramuscular nerves may be pathologic and associated with muscle fiber denervation atrophy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 360, 15 January 2016, Pages 84-87
نویسندگان
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