کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8278107 | 1535125 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A model of acute compressive spinal cord injury with a minimally invasive balloon in goats
ترجمه فارسی عنوان
یک مدل آسیب فیزیکی حاد ستون فقرات با یک بالون مهاجم حداقل در بز
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کلمات کلیدی
آسیب نخاعی، مدل فشرده سازی، مدل آسیب دیدگی بز ها، حداقل تهاجمی فشرده سازی بالون،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Research into spinal cord injury depends upon animal models of trauma. While investigations using small animals have yielded critical insights into the cellular mechanisms of neurotrauma, no effective therapies have been translated to human clinical treatments. There are considerable differences in pathophysiology, scale, and anatomical organization between rodents and primates. Here, the established method of inflating balloons to compress the cord within the spinal canal was adapted for use in goats. By using surgical techniques to insert a kyphoplasty balloon, spinal cord injury was accomplished with minimal trauma to the surrounding tissues, as is common in other traumatic models. Dye volumes of 0, 1.26 ± 0.18, and 2.82 ± 0.20 mL were injected into the balloon to produce spinal occupancies of 0%, 33 ± 2%, and 89 ± 4%, as evaluated by X-ray and computerized tomography imaging. A significant dose response was observed for the different levels of trauma, with reduced conduction of somatosensory evoked potentials and impaired mobility 7 days after injury. From the strong correlations between injection volume, balloon pressure, spinal occupancy, nerve function, and animal behavior, we conclude that hydraulic compression in goats is a useful model of spinal cord injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 337, Issues 1â2, 15 February 2014, Pages 97-103
Journal: Journal of the Neurological Sciences - Volume 337, Issues 1â2, 15 February 2014, Pages 97-103
نویسندگان
Peng Cao, Yuhuang Zheng, Tao Zheng, Changwei Sun, Jiong Lu, Todd Rickett, Riyi Shi,