کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8278579 | 1535126 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacological modulation of cognitive and behavioral symptoms in patients with dementia due to Alzheimer's disease
ترجمه فارسی عنوان
مدولاسیون فارماکولوژیک علائم شناختی و رفتاری در بیماران مبتلا به زوال عقل به علت بیماری آلزایمر
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کلمات کلیدی
بیماری آلزایمر، اختلالات شناختی، کم خونی بیماری های نوروژنیک، عصبشناسی، دارودرمانی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
To evaluate correlations of pharmacological treatment with cognitive and behavioral symptoms in patients with dementia due to Alzheimer's disease with low schooling, subjects were assessed for demographic features, neuropsychiatric symptoms, cognitive decline, functionality, caregiver burden, APOE haplotypes and pharmacological treatment. Among 217 patients, use of cholinesterase inhibitors with or without Memantine was associated with less neuropsychiatric symptoms, while anti-psychotics and/or anti-epileptic drugs were associated with lower instrumental functionality. Anti-psychotics were also associated with more neuropsychiatric symptoms in moderately impaired patients, possibly reflecting the greater need for such treatment when behavioral symptoms are present. Patients receiving more medications were usually younger, obese, married, with higher schooling and more neuropsychiatric symptoms. APOE4Â + haplotypes were correlated with earlier dementia onset, but not with pharmacological treatment. Higher caregiver burden was associated with more psychotropic drugs. A trend was found for treatment with cholinesterase inhibitors and Memantine to be associated with longer lengths of dementia for moderately impaired but not for severely impaired patients, regardless of APOE haplotypes, translating into a synergistic effect among such medications for slowing cognitive decline but not for prolonging survival. Further longitudinal studies may be required to assess dose-response relationships regarding treatment with psychotropics for patients with dementia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 336, Issues 1â2, 15 January 2014, Pages 103-108
Journal: Journal of the Neurological Sciences - Volume 336, Issues 1â2, 15 January 2014, Pages 103-108
نویسندگان
Fabricio Ferreira de Oliveira, Paulo Henrique Ferreira Bertolucci, Elizabeth Suchi Chen, Marilia de Arruda Cardoso Smith,