Decreases in GSH:GSSG activate vascular endothelial growth factor receptor 2 (VEGFR2) in human aortic endothelial cells

Changes in GSH:GSSG but not ROS alone activates VEGFR2. This is a brief summary of the manuscript demonstrating that the addition of exogenous H2O2 is insufficient to activate VEGFR2; however decreasing GSH:GSSG results in ligand independent activation of VEGFR2.125