کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8286758 1535837 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits
ترجمه فارسی عنوان
اعمال غیر خطی عوامل فیزیولوژیکی: اختلالهای محدود باعث مزایای تناسب اندام می شود
کلمات کلیدی
پاسخ غیر خطی، عوامل فیزیولوژیکی، مواد مغذی گونه های اکسیژن واکنش پذیر، طول عمر، پیش شرط بندی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Finite disarrangements of important (vital) physiological agents and nutrients can induce plethora of beneficial effects, exceeding mere attenuation of the specific stress. Such response to disrupted homeostasis appears to be universally conserved among species. The underlying mechanism of improved fitness and longevity, when physiological agents act outside their normal range is similar to hormesis, a phenomenon whereby toxins elicit beneficial effects at low doses. Due to similarity with such non-linear response to toxins described with J-shaped curve, we have coined a new term “mirror J-shaped curves” for non-linear response to finite disarrangement of physiological agents. Examples from the clinical trials and basic research are provided, along with the unifying mechanisms that tie classical non-linear response to toxins with the non-linear response to physiological agents (glucose, oxygen, osmolarity, thermal energy, calcium, body mass, calorie intake and exercise). Reactive oxygen species and cytosolic calcium seem to be common triggers of signaling pathways that result in these beneficial effects. Awareness of such phenomena and exploring underlying mechanisms can help physicians in their everyday practice. It can also benefit researchers when designing studies and interpreting growing number of scientific data showing non-linear responses to physiological agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Redox Biology - Volume 13, October 2017, Pages 235-243
نویسندگان
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