کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8287622 | 1535861 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Langerhans cell precursors acquire RANK/CD265 in prenatal human skin
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کلمات کلیدی
SCFTGF-βTNFchemokine (C–C motif) ligand 5GM–CSFEGATregCcl5BMP7Transforming Growth Factor Beta - تبدیل بتا فاکتور رشدEstimated gestational age - تخمینی تخمینی بارداریRank - رتبهDevelopment - رشدRegulatory T cell - سلول T تنظیم کنندهDendritic cell - سلول دندریتیکLangerhans cell - سلول لانگرهانسLangerhans cells - سلول های لانگرهانسgranulocyte–macrophage colony-stimulating factor - عامل گرانولوسیت-ماکروفاژ colony-stimulating factorStem Cell Factor - فاکتور سلول بنیادیtumor necrosis factor - فاکتور نکروز تومورPrenatal - قبل از تولدbone morphogenetic protein 7 - پروتئین مورفوژنیک استخوان 7Skin - پوستprecursor - پیشگام
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The skin is the first barrier against foreign pathogens and the prenatal formation of a strong network of various innate and adaptive cells is required to protect the newborn from perinatal infections. While many studies about the immune system in healthy and diseased adult human skin exist, our knowledge about the cutaneous prenatal/developing immune system and especially about the phenotype and function of antigen-presenting cells such as epidermal Langerhans cells (LCs) in human skin is still scarce. It has been shown previously that LCs in healthy adult human skin express receptor activator of NF-κB (RANK), an important molecule prolonging their survival. In this study, we investigated at which developmental stage LCs acquire this important molecule. Immunofluorescence double-labeling of cryostat sections revealed that LC precursors in prenatal human skin either do not yet [10-11 weeks of estimated gestational age (EGA)] or only faintly (13-15 weeks EGA) express RANK. LCs express RANK at levels comparable to adult LCs by the end of the second trimester. Comparable with adult skin, dermal antigen-presenting cells at no gestational age express this marker. These findings indicate that epidermal leukocytes gradually acquire RANK during gestation - a phenomenon previously observed also for other markers on LCs in prenatal human skin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 117, Issues 4â5, MayâJune 2015, Pages 425-430
Journal: Acta Histochemica - Volume 117, Issues 4â5, MayâJune 2015, Pages 425-430
نویسندگان
Alice Schöppl, Albert Botta, Marion Prior, Johnnie Akgün, Christopher Schuster, Adelheid Elbe-Bürger,