کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8287662 | 1535861 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Different pediatric brain tumors are associated with different gene expression profiling
ترجمه فارسی عنوان
تومورهای مختلف مغز کودکان با مشخصات ژنی متفاوت بیان می شوند
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کلمات کلیدی
Lysosomal proteaseCTSCEPMGBMcTBSCHIT1TP53CTSKCHI3L1Ependimoma - Ependymomapilocytic astrocytoma - آستروسیتوم پلوتونیومgamma-aminobutyric acid - اسید گاما آمینو بوتیریکMED - باChia - تقسیم کردنtumor protein p53 - تومور پروتئین p53Medulloblastoma - مدولو بلاستوماNormal brain - مغز عادیChitobiase - چیتوبایسCathepsin C - کاتئهپسین CCathepsin F - کاترپسین فchitotriosidase - کیتوتریوزیدازChitinases - کیتینازهاcyclin-dependent kinases - کیناز وابسته به سیکلینGlioblastoma - گلیوبلاستوما
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Malignant brain tumors are the most common pediatric solid tumors and are the leading cause of death from childhood cancers. These tumors include several histologic subtypes. Due to the particular properties of brain tumors, such as growth and division, examination of brain tumors and the analysis of results are not simple. Up to date there is a dearth of useful biomarkers that have been validated and clinically implemented for pediatric brain tumors. In order to identify the new genetic alterations we recognized, using microarray dataset, chitinases as new potential biomarkers of CNS tumors. The modulation of chitinases was confirmed also in the different histologic subtypes. Our study revealed that distinct patterns of chitinases expression characterize the diverse histological subtypes. In addition evaluating other lisosomal enzymes such as glycosidases and proteases we found that NEU4, CTBS and GBA2 belonging to glycosidases family and CTSC, CTSK and CTSF belonging to proteases family were differently modulated. Future investigations are needed to be performed before some of these enzymes could finally be used as biomarkers of specific types of CNS neoplasms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 117, Issues 4â5, MayâJune 2015, Pages 477-485
Journal: Acta Histochemica - Volume 117, Issues 4â5, MayâJune 2015, Pages 477-485
نویسندگان
Michelino Di Rosa, Cristina Sanfilippo, Massimo Libra, Giuseppe Musumeci, Lucia Malaguarnera,