کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8319001 | 1539255 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fluorescent light exposure incites acute and prolonged immune responses in zebrafish (Danio rerio) skin
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Artificial light produces an emission spectrum that is considerably different than the solar spectrum. Artificial light has been shown to affect various behavior and physiological processes in vertebrates. However, there exists a paucity of data regarding the molecular genetic effects of artificial light exposure. Previous studies showed that one of the commonly used fluorescent light source (FL; 4100 K or “cool white”) can affect signaling pathways related to maintenance of circadian rhythm, cell cycle progression, chromosome segregation, and DNA repair/recombination in the skin of male Xiphophorus maculatus. These observations raise questions concerning the kinetics of the FL induced gene expression response, and which biological functions become modulated at various times after light exposure. To address these questions, we exposed zebrafish to 4100 K FL and utilized RNA-Seq to assess gene expression changes in skin at various times (1 to 12 h) after FL exposure. We found 4100 K FL incites a robust early (1 â 2h) transcriptional response, followed by a more protracted late response (i.e., 4-12 h). The early transcriptional response involves genes associated with cell migration/infiltration and cell proliferation as part of an overall increase in immune function and inflammation. The protracted late transcriptional response occurs within gene sets predicted to maintain and perpetuate the inflammatory response, as well as suppression of lipid, xenobiotic, and melatonin metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 208, June 2018, Pages 87-95
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 208, June 2018, Pages 87-95
نویسندگان
Trevor J. Gonzalez, Yuan Lu, Mikki Boswell, William Boswell, Geraldo Medrano, Sean Walter, Samuel Ellis, Markita Savage, Zoltan M. Varga, Christian Lawrence, George Sanders, Ronald B. Walter,