Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels

- HNTX-IV is an antagonist of Nav1.7 with high selectivity over other VGSC subtypes.
- The binding site for HNTX-IV was determined as the S3-S4 linker of Nav1.7 domain II.
- The toxin-channel complex was constructed by in silico docking.