Keywords: Nav1.7; Pain; Pharmacophore models; Molecular docking; Structure activity relationship;
مقالات ISI (ترجمه نشده)
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Keywords: Sodium channel; Nav1.7; Acidosis; Sensoy neuron; Pain;
Keywords: Loperamide; Opioid receptor; Pain; Nav1.7; Sodium channel; MOR; mu-opioid receptor; VGSCs; Voltage-gated sodium channels; HEK; human embryo kidney; KO; knock-out; PWF; paw withdrawal frequency; CFA; complete Freund's adjuvant; DRG; dorsal root ganglion; P
Keywords: Neuropathic pain; Sodium channel; Nav1.7; Dibenzazepine; Dibenzoxazepine;
Keywords: Benzazepinone; Sodium channel; Nav1.7;
1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition
Keywords: 3-(Sulfonyl)-1,2,4-triazole; Triazolesulfone; Bioisostere; Acylsulfonamide; pKa; Sodium channel; NaV1.7; NaV1.5; Pain;
CRMP2-Neurofibromin Interface Drives NF1-related Pain
Keywords: ANOVA; analysis of variance; AP; action potential; Cas9; CRISPR-associated protein-9 nuclease; CaV2.2; N-type voltage-gated calcium channel; CGRP; calcitonin gene-related peptide; CNRP1; CRMP2-neurofibromin regulating peptide 1; CRISPR; clustered regula
Nav1.7 inhibitors for the treatment of chronic pain
Keywords: Nav1.7; SCN9A; Voltage gated sodium channel; Pain;
Research articleMechanism of inhibition by chlorpromazine of the human pain threshold sodium channel, Nav1.7
Keywords: Chlorpromazine; Voltage-gated sodium channel; Nav1.7; Pain; Calmodulin inhibitory peptide;
Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice
Keywords: Nav1.7; Ion channel; Pain; Arylsulfonamide; Selectivity;
Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors
Keywords: Sodium channel; NaV1.7; NaV1.5; State-dependent; Pain;
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement
Keywords: NaV1.7; voltage gated sodium channel 1.7; SCN9A; sodium voltage-gated channel alpha subunit 9; TM; transmembrane; VSD; voltage sensing domain; CLu; unbound clearance; HLM; human liver microsome; RLM; rat liver microsome; PX; patch express; LLE; ligand lip
Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level
Keywords: Peimine; Nav1.7; Kv1.3; Inflammation; Pain; Fritillaria
Oxidation differentially modulates the recombinant voltage-gated Na+ channel α-subunits Nav1.7 and Nav1.8
Keywords: TTX; tetrodotoxin; Nav; voltage-gated sodium channel; TRP; transient receptor potential; HEK; human embryonic kidney; EGFP; green fluorescent protein; DRG; dorsal root ganglion; Nociception; Pain; Oxidative stress; Sodium channel; Nav1.7; Nav1.8;
A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain
Keywords: Chronic pain; NMDA; GluN2B; Nav1.8; Nav1.7; Substituted aminoquinoline
N-Aryl azacycles as novel sodium channel blockers
Keywords: ARXQEUXKXBDCRA-JJRNEHELSA-N; XJOGDSABVMVHKS-UHFFFAOYSA-N; GAFPQLZAICTDSD-MZGUNHGESA-N; Neuropathic pain; Sodium channel; Nav1.7; Azacycle;
Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1
Keywords: Voltage-gated sodium channel; NaV1.7; Peptide antagonist; Peptide toxin;
Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels
Keywords: VGSCs; Nav1.7; Tarantula toxin; Voltage sensor;
Discovery of pyrrolo-benzo-1,4-diazines as potent Nav1.7 sodium channel blockers
Keywords: Nav1.7; Nav1.5; Pain; Sodium channel blockers; Pyrrolo-benzo-1,4-diazine;
The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Nav1.7
Keywords: Benzenesulfonamide; Sodium channel; Nav1.7; Pain
Bioavailable pyrrolo-benzo-1,4-diazines as Nav1.7 sodium channel blockers for the treatment of pain
Keywords: Nav1.7; Nav1.5; Sodium channel; Pain;
Channelopathies, painful neuropathy, and diabetes: which way does the causal arrow point?
Keywords: diabetes mellitus; diabetic neuropathy; painful neuropathy; sodium channelopathy; NaV1.7; β cells;
Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena
Keywords: ACF; animal-component free; BSA; bovine serum albumin; CaCl2; calcium chloride; CD; circular dichroism spectroscopy; CHO; Chinese hamster ovary; CNS; central nervous system; CO2; carbon dioxide; CsF; cesium fluoride; CsOH; cesium hydroxide; DIC; diisoprop
mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK
Keywords: Rapamycin; Sensory neurons; mTOR; ERK; Nav1.7; AMPK;
The scorpion toxin Amm VIII induces pain hypersensitivity through gain-of-function of TTX-sensitive Na+ channels
Keywords: Voltage-gated sodium channels; Nav1.7; Nav1.8; Nav1.9; Excitability; Sensory neurons; Allodynia; Hyperalgesia; Pain; Scorpion toxins;
Differential effect of D623N variant and wild-type Nav1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons
Keywords: Small fiber neuropathy; Dorsal root ganglia; Hyperexcitability; Sodium channel; NaV1.7; Hodgkin-Huxley;
Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons
Keywords: Gabapentin; Painful diabetic neuropathy; Nav1.7; p-ERK1/2; Dorsal root ganglion
Protein Kinase B/Akt Is Required for Complete Freund's Adjuvant-Induced Upregulation of Nav1.7 and Nav1.8 in Primary Sensory Neurons
Keywords: Nav1.7; Nav1.8; Akt; dorsal root ganglion; inflammatory pain
Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists
Keywords: Nav1.7; Voltage-gated sodium channels; Nav channels; Sodium channel blockers; Sodium channel inhibitors; Sodium channel antagonists; Congenital indifference to pain; Paroxysmal extreme pain disorder; Primary erythromelalgia; Aminopyrimidinone;
The discovery of aminopyrazines as novel, potent Nav1.7 antagonists: Hit-to-lead identification and SAR
Keywords: Nav1.7; Analgesia; Sodium channels; Aminopyrazine;
Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Nav1.7 antagonists
Keywords: Nav1.7; Voltage-gated sodium channels; Nav channels; Sodium channel blockers; Sodium channel inhibitors; Sodium channel antagonists; Congenital indifference to pain; Paroxysmal extreme pain disorder; Primary erythromelalgia; Pyrrolopyrimidine;
Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads
Keywords: Spider venom; Peptide; Inhibitor cystine knot; Voltage-gated sodium channel; Therapeutic; Analgesic; Insecticide; ArachnoServer; NaV1.7;
NaV1.7 accumulates and co-localizes with phosphorylated ERK1/2 within transected axons in early experimental neuromas
Keywords: Neuropathic pain; Nerve injury; Neuroma; Voltage-gated sodium channels; NaV1.7; Mitogen-activated protein kinases; ERK1/2; p38
Transcriptional up-regulation of cell surface NaV1.7 sodium channels by insulin-like growth factor-1 via inhibition of glycogen synthase kinase-3β in adrenal chromaffin cells: enhancement of 22Na+ influx, 45Ca2+ influx and catecholamine secretion
Keywords: Na+ channel; NaV1.7; Insulin-like growth factor-1; Glycogen synthase kinase-3β; Up-regulation; Chromaffin cell; Catecholamine secretion;
Human embryonic kidney (HEK293) cells express endogenous voltage-gated sodium currents and Nav1.7 sodium channels
Keywords: HEK293 cells; Sodium channels; Nav1.7; Tetrodotoxin; Tefluthrin
Two novel SCN9A mutations causing insensitivity to pain
Keywords: SCN9A; Channelopathy-associated insensitivity to pain; Congenital indifference to pain; NaV1.7; Olfaction; Indifference to pain; CIP;
Association analysis of SCN9A gene variants with borderline personality disorder
Keywords: Borderline personality disorder; Dissociation; Genetics; Haplotype; Candidate gene; SCN9A; Nav1.7
Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain
Keywords: Sodium channel; Neuropathic pain; Nav1.7; Benzazepinone; Benzodiazepine
Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain
Keywords: Sodium channel; Nav1.7; Neuropathic pain; Benzazepinone