Transcriptional up-regulation of cell surface NaV1.7 sodium channels by insulin-like growth factor-1 via inhibition of glycogen synthase kinase-3β in adrenal chromaffin cells: enhancement of 22Na+ influx, 45Ca2+ influx and catecholamine secretion

► Effects of IGF-1 on expression and function of NaV1.7 Na+ channels are investigated. ► IGF-1 up-regulates NaV1.7 Na+ channels via acceleration of α-subunit gene transcription. ► PI3K∼Akt∼GSK-3β pathway is involvement in the increasing effect of IGF-1. ► IGF-1 enhances Na+ influx, and subsequent Ca2+ influx and catecholamine secretion.