Molecular basis of the inhibition of the fast inactivation of voltage-gated sodium channel Nav1.5 by tarantula toxin Jingzhaotoxin-II

- JZTX-II inhibits the fast inactivation of Nav1.5 with high selectivity over other VGSC subtypes.
- The binding site for JZTX-II was determined as the S3-S4 linker of Nav1.5 domain IV.
- D1609 might be the main determinant involved in the selectivity of JZTX-II on the VGSC subtypes.